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Increlex is a form of recombinant IGF‑1 used to treat growth failure in children aged 2 years and older with severe primary IGF‑1 deficiency, under specialist supervision.
Increlex (mecasermin) is a prescription medication that contains recombinant human insulin-like growth factor-1 (IGF-1). It is used for the treatment of a rare medical condition known as growth hormone insensitivity syndrome (GHIS), also referred to as insulin-like growth factor-1 deficiency (IGFD).
What Increlex is
- Increlex contains mecasermin, a man‑made (recombinant) insulin‑like growth factor‑1 (IGF‑1)
- IGF‑1 is a hormone essential for normal childhood growth, supporting bone and muscle development
- It is not a substitute for growth hormone and is not used for children whose short stature is due to growth hormone deficiency, malnutrition, hypothyroidism, or chronic steroid use
Generic Name: Mecasermin
Brand name: Increlex
GHIS is a genetic disorder characterized by a lack of response to growth hormone (GH), which leads to short stature and poor growth in affected individuals. Normally, GH is produced by the pituitary gland and stimulates the production of IGF-1 in the liver. IGF-1 plays a crucial role in promoting the growth and development of bones, muscles, and other tissues.
However, individuals with GHIS have a defect in the GH receptor or related signaling pathways, which results in reduced production of IGF-1 and impaired growth. Increlex, being a form of recombinant IGF-1, can help address this deficiency and promote linear growth in children with GHIS.
Key points about Increlex:
Indication: Increlex is indicated for the long-term treatment of children with growth failure due to severe primary IGF-1 deficiency (GHIS/IGFD) or with GH gene deletion who have developed neutralizing antibodies to GH.
Administration: Increlex is administered by subcutaneous (under the skin) injection. It is usually given once or twice daily, depending on the specific treatment plan recommended by the healthcare provider.
Monitoring: Regular monitoring of growth and IGF-1 levels is essential to adjust the dose and ensure optimal treatment outcomes.
Adverse Effects: Like any medication, Increlex can have side effects. Common side effects may include injection site reactions, headaches, and low blood sugar (hypoglycemia). Your doctor will monitor for these and other potential side effects.
Contraindications: Increlex should not be used in individuals with a known hypersensitivity to mecasermin or any of its components.
Usage in Athletes: It’s important to note that IGF-1, including Increlex, has been abused by some athletes and bodybuilders for its potential to enhance muscle growth and performance. However, such use is not approved and can lead to serious health risks.
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Verified Analytical Purity: Every lot is verified via advanced HPLC and mass spectrometry testing methods.
Fast USA & European Shipping: Direct, temperature-controlled delivery pathways across North America and Europe.
Compliant Documentation: Detailed Certificates of Analysis (CoA) and Safety Data Sheets (SDS) provided with every batch.
Dedicated Client Support: Real-time tracking and expert technical assistance available for all customer orders.
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Time-sensitive scientific projects demand reliable delivery partners. Mind Botanical Lab provides fast and secure shipping of Increlex directly to authorized facilities across the United States, Canada, the United Kingdom, and all EU member states. All shipments feature real-time tracking, tamper-evident seals, and cold-chain thermal packaging when necessary to maintain compound stability.
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Quality Assurance & Purity Standards for Increlex
Quality assurance is central to everything we do. Our Increlex reference standards comply with multi-step quality control benchmarks, including identity testing, assay strength verification, and purity testing. Digital CoAs and safety documentation can be accessed directly through our online portal prior to ordering.
Frequently Asked Questions About Buying Increlex Online
What purity level can I expect when ordering Increlex from Mind Botanical Lab? All Increlex (mecasermin) supplied by Mind Botanical Lab meets high analytical research standards, typically testing at top purity thresholds with complete batch CoAs provided.
How fast is delivery to destinations in the USA and Europe? Domestic US shipments arrive within 2–4 business days via express freight. European orders are processed through regional fulfillment nodes and typically arrive within 3–5 business days.
Can I order Increlex in bulk or wholesale quantities? Yes, Mind Botanical Lab provides standard catalog sizes as well as custom bulk quantities for authorized institutional clients. Contact our sales team for a custom quote on volume orders.
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Please note that Increlex is a prescription medication, and you should consult a qualified veterinarian before administering it to your pet. Mind Botanica Lab encourages responsible and informed pet healthcare decisions.
Who Increlex is for
- Height SDS ≤ –3.0, and
- Basal IGF‑1 SDS ≤ –3.0, and
- Normal or elevated growth hormone levels
It is also used in children with growth hormone gene deletion who have developed neutralizing antibodies to GH
Who should not receive Increlex
- Have cancer or a history of cancer.
- Have closed growth plates (finished growing).
- Are allergic to mecasermin or its ingredients.
- Are younger than 2 years old.
- Are infants (due to benzyl alcohol toxicity risk).
How Increlex works
- It replaces missing IGF‑1, allowing normal growth processes to occur
- IGF‑1 stimulates cell division, nutrient uptake, and tissue growth, helping children grow in height
How it is given
- Administered by subcutaneous injection, never into a vein
- Given twice daily, 20 minutes before or after a meal or snack to reduce hypoglycemia risk
- Dosing is individualized based on weight and tolerability; typical starting doses are 0.04–0.08 mg/kg, increasing up to 0.12 mg/kg twice daily if tolerated
- Missed doses should not be doubled
Major safety concerns
- The most common and serious risk; can cause seizures or unconsciousness
- Children must eat around dosing and have access to fast‑acting sugar sources.
- Symptoms include headache, nausea, vomiting, and vision changes
- Eye exams are recommended at initiation and periodically.
- Can cause snoring, sleep apnea, or ear problems
- Causes hip/knee pain or limping; requires urgent medical evaluation
- Due to rapid growth; monitoring is required
- Reports of malignant tumors exist, especially at higher-than-recommended doses or in children already at increased cancer risk
- Treatment must stop if a tumor develops.
Common side effects
- Low blood sugar
- Injection site reactions (pain, redness, bruising)
- Allergic reactions
- Enlarged tonsils
Storage and handling
- Store in the refrigerator, protect from light, do not freeze
- Discard 30 days after opening
Key takeaway
Important safety information
Contraindications
- Hypersensitivity: to mecasermin (rhIGF-1), any of the inactive ingredients inIncrelex , or who have experienced a severe hypersensitivity toIncrelex . Allergic reactions have been reported, including anaphylaxis requiring hospitalization.
- Closed Epiphyses
- Malignant Neoplasia in pediatric patients with malignant neoplasia or a history of malignancy.
Warning and precautions
- Hypoglycemia: Increlex should be administered 20 minutes before or after a meal or snack and should not be administered when the meal or snack is omitted. Glucose monitoring and Increlex dose titration are recommended until a well-tolerated dose is established and as medically indicated.
- Intracranial Hypertension: Funduscopic examination is recommended at the initiation of and periodically during the course of therapy.
- Lymphoid Tissue Hypertrophy: Patients should have periodic examinations to rule out potential complications.
- Slipped Capital Femoral Epiphysis: Slipped capital femoral epiphysis may lead to osteonecrosis. Cases of slipped capital femoral epiphysis with or without osteonecrosis have been reported in pediatric patients receiving products indicated to treat growth failure and/or short stature, includingIncrelex . Carefully evaluate any pediatric patient with the onset of a limp or hip/knee pain during Increlex therapy.
- Progression of Scoliosis: Patients with a history of scoliosis, treated withIncrelex , should be monitored.
- Malignant Neoplasia: There have been postmarketing reports of malignant neoplasia in pediatric patients who received treatment withIncrelex . It is unknown whether there is any relationship between Increlex therapy and new occurrences of neoplasia. The tumors were observed more frequently in patients who received Increlex at higher than recommended doses or at doses that produced serum IGF-1 levels above the normal reference ranges for age and sex. Monitor all patients receiving Increlex carefully for development of neoplasms. If malignant neoplasia develops, discontinue Increlex treatment.
- Risk of Serious Adverse Reactions in Infants due to Benzyl Alcohol Preserved Solution: Serious and fatal adverse reactions including “gasping syndrome” can occur in neonates and infants treated with benzyl alcohol-preserved drugs. Use of Increlex in infants is not recommended.
Adverse reactions
Common adverse reactions include hypoglycemia, local and systemic hypersensitivity, and tonsillar hypertrophy.
To report a suspected adverse event related to INCRELEX, contact Eton Pharmaceuticals, Inc. at 1-855-224-0233 or the U.S. Food and Drug Administration (FDA) at www.fda.gov/safety/Medwatch
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